what is the goal? Cross-language derivation does not work w/o an intermediate class (i.e. the GetMyInt() method will not be overridden in the example as you show it here; and the instantiated class, if it were to be made possible, could not be used).
I want to write a base class in C++, so that I can write an instantiated class in python. if not possible, I have to write the instantiated class in C++, and then call it in python.
for C++ to call the derived class, a vtable entry needs to exist, so the C++ compiler needs to fill that. Normally, this is done by writing a forwarding class in C++ (see e.g. TPySelector and the various fitter base classes). It’s not automatically possible at this point in time (I prototyped this with ACLiC, which was a bit of a kludge; it should be easy with Cling).