Cannot access file in python "unsafe use of relative rpath"

This is the same error message I get from the system python, therefore I assume you build ROOT against the system python and not homebrew. You can check which python you built against with this command:

grep "/python$" root-build-dir/CMakeCache.txt

I am avoiding using the system python and building ROOT against the version provided from macports (the same can be done with homebrew). macports provides a simple method to set there version as the default in the path and I suspect something like that exists for homebrew as well. After that the build of ROOT will use the non system python by default. Alternatively, you can force CMake to use a specific version of python with the following:

cmake root-source -DPYTHON_EXECUTABLE=/usr/local/bin/python